Nouvelles 2019

Cette section vous fera découvrir les plus récents travaux des membres de la SQHA. Chaque mois, vous trouverez le résumé d’un nouvel article scientifique publié par un de nos membres, ainsi qu’un lien vous permettant d’aller lire l’article scientifique en question.

• Le knock-down de miR-31 protège contre l’hypertension et les blessures vasculaires induites par l’angiotensine II

  Huo KG, Richer C, Berillo O, Mahjoub N, Fraulb-Aquino JC, Barhoumi T, Ouerd S, Coelho Sc, Sinnett D, Paradis P, Schiffrin EL.

  Vascular injury is an early manifestation in hypertension and a cause of end-organ damage. MicroRNAs play an important role in cardiovascular disease, but their implication in vascular injury in hypertension remains unclear. This study revealed using an unbiased approach, microRNA and mRNA sequencing with molecular interaction analysis, a microRNA-transcription factor coregulatory network involved in vascular injury in mice made hypertensive by 14-day Ang II (angiotensin II) infusion. A candidate gene approach identified upregulated miR-431-5p encoded in the conserved 12qF1 (14q32 in humans) microRNA cluster, whose expression correlated with blood pressure, and which has been shown to be upregulated in human atherosclerosis, as a potential key regulator in Ang II-induced vascular injury. Gain- and loss-of-function in human vascular smooth muscle cells demonstrated that miR-431-5p regulates in part gene expression by targeting ETS homologous factor. In vivo miR-431-5p knockdown delayed Ang II-induced blood pressure elevation and reduced vascular injury in mice, which demonstrated its potential as a target for treatment of hypertension and vascular injury.

  Hypertension. 2019 Apr 1:HYPERTENSIONAHA11912619.
  doi: 10.1161/HYPERTENSIONAHA.119.12619. [Epub ahead of print]